History

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4000BC

Earliest recorded use of opioid

3400BC

The Sumerians referred to the opium poppy as “Hul Gil” – the “Joy Plant”

1300BC

Usage of Opium in Egypt spreads to Greece and rest of Europe

460BC

Opium recognized for its medical benefits by Hippocrates

330 BC
-AD 400

Use of Opioid spreads to Persia, India, and China

1300

During the Inquisition, Opium got missing from Europe

1527

Reintroduction of opium in Europe by Paracelsus for medicinal purposes

1729

Opium banded by Emperor Cheng of China apart from its use as medicine

1803

German scientist abstracted morphine, "God's own medicine" from opium

1853

Opium injection started with the invention of Hypodermic needle

1874

Development of Heroin with twice the potency of morphine

1914

Harrison Act enforced lying heavy tax on opioids

1924

In USA, Non-medical use of opioid banned

1965
-1970

Heroin users mark reached about 750,000 in USA

1984

Vicodin® (acetaminophen/hydrocodone bitartrate) receives FDA approval (Vicodin is a registered trademark of Abbott Laboratories)

1995

Oxycontin® (oxycodone HCl) receives FDA approval (Oxycontin is a registered trademark of Purdue Pharma L.P.)

1996

A Study shown that 2.9 million people have used heroin at least once in their lifetimes and also that around 87% of first-time heroin users are younger than age 26.

1999

Percocet® (oxycodone HCl/acetaminophen) receives FDA approval (Percocet is a registered trademark of Endo Laboratories, Inc.). SUBUTEX® (buprenorphine HCl sublingual tablets) got approved in France for treating opioid dependence.

2000

US approved the Drug Addiction Treatment Act

2001

SUBUTEX approved in Australia for treating opioid dependence. 2.5 million People in the US use opioid painkillers recreationally for the first time.

2002

The FDA approved SUBOXONE in the US

2003

Around 1.6 to 2.4 million Americans become dependent on heroin or opioid painkillers. SUBOXONE marketed for the first time for treating opioid dependence.